About Us

At Cellvax Therapeutics, we develop a proprietary cell-based cancer immunotherapy.

Our lead product, FK-PC101, is for the treatment of the prostate cancer patient with a higher risk of recurrence after prostatectomy. FK-PC101 is based on its proprietary novel technology using the patient's own cancer cells to create specific Tumor Presenting Cells (TPC). Patients immunized with a personalized TPC have a multi-neoantigen immune response against cancer cells with a significant clinical response.

Not necessary long hours of infusion

Our Team

Fernando Kreutz, PhD.Company CEO

Fernando Kreutz

Fernando Kreutz is a biotechnology doctor with more than 20 years of experience in cancer research. He shares a vast knowledge in clinical R&D in the pharma industry, having successfully registered patents for solid tumors in prostate cancer, and opening ground for the expansion of his technology throughout all solid tumors. Dr. Kreutz earned a Ph.D. in - Pharmacy and Pharmaceutical Science from the University of Alberta.

Dr. Kreutz pioneering research on the 90’s lead to discovery that cancer cells treated with hIFN-y presented MHC Class II making it possible the activation of CD4+ helper T cells - which play a central role in the immune system.

By developing a personalized vaccine with the patient's tumor cells he found a way to make the immune system effectively detect and attack cancer cells.

Through further investigation and development Dr. Kreutz founded Cellvax Therapeutics - a Biotechnology company focused on developing new therapeutics for chronic diseases.

Sam Silva, PhD.VP of Business Development

Sam Silva

Sam brings several years of experience in the pharmaceutical industry. He has held leadership roles from small biopharma ventures to big pharma organizations. He brings expertise with small and large molecules as well as biologics. As a pharmaceutical executive, Sam has led global drug development teams and launched new drugs in the US and Europe.

Sam has a successful track record in drug development, technology licensing and acquisition with over 30 transactions.

Sam holds a Ph.D. from the University of the Sciences in Philadelphia.

Personalize your treatment

History

History

Cellvax Therapeutics is a privately held clinical stage company founded by entrepreneur PhD. MD. Fernando Thomé Kreutz. The company is active in research, development and innovation on human immunodiagnosis and autologous anticancer vaccine. Cellvax Therapeutics has developed a proprietary autologous tumor cell-based cancer immuno-therapy platform.

Pioneer in developing a therapy that aims to stimulate the immune system to recognize the abnormality of tumor cells and destroy them, the autologous cell vaccine is made from the tumor cells of the patient and generates a strong immune response.

The company has completed Phase I and Phase II clinical trials in Brazil, and has had a successful pre-IND meeting with FDA for the upcoming Phase 2/3 pivotal trials in the U.S..

Products

Anti-Cancer Vaccine

FK-PC101 is a novel personalized immunotherapy presenting patients owns tumor neoantigens. It has a dual mode of action, being capable of activating both CD8+ cytotoxic T cells and CD4+ helper T cells, and thereby resulting in a strong and specific anti-cancer immune response. Upon injection, FK-PC101 will not only present a cancer neoantigen in the context of MHC I to naïve (unprimed ) CD8 + cytotoxic T cells, but also present the non-self antigen to CD4 + helper T cells in the context of MHC II.

FK-PC101 consists of autologous human cancer cells which have been modified ex vivo to express Major Histocompatibility Complex (MHC) II on their surface.

Cellvax Therapeutics is the only company developing a cancer immunotherapy platform that converts a patient's own cancer cells to an antigen-presenting state (“Tumor Presenting Cells”). The process involves cultivating tumor cells with a combination of cytokines in a specific media, which stimulates the de novo expression of MHC class II molecules on the surface of tumor cells. Solid tumor cells, similar to other non-immunological cells, do not naturally present MHC class II, a molecule critically responsible for peptide presentation to T helper cells to trigger an immune response. These modified tumor cells (“Tumor-Presenting Cells”) are then incubated with a foreign antigen, which is then internalized, processed, and displayed by the cells.

Cellvax Therapeutics estimates that FK-PC101 can reduce PSA recurrences in men with localized prostate cancer after RP. In addition, Cellvax Therapeutics proprietary technology platform has applicability to other solid tumor treatment (e.g. breast, colon, pancreatic, others).

FK-PC101 is administered intradermal once weekly for 4 weeks, followed by inoculation once monthly for the next two months, and the last (seventh) inoculation three months after the last monthly dose. Phase I and II clinical trials were conducted in Brazil using patients presenting with local advanced or metastatic prostate cancer. Results from a Phase II clinical study provide evidence that at 4 years post-RP, 11.8% of the vaccine group had experienced PSA recurrence, vs. 36.8% in the control group (p=0.0453, z-test).

Classic anti-tumor response

Convention “Too Little, Too Late” Immune Response:

  • Pathway
    Tumor cells present tumor peptides on cell surface via MHC Class I, atrracting a T Cell response.
  • Limitation
    • Minimal activation of immune pathway;
    • No interaction with T Helper cells;
    • Single Antigen response limits signal.

Novel approach

Vax-P - Tumor Presenting Cells - TPCs:

  • Pathway
    Tumor Preseting Cells are cultivated with a foreign antigen and activated for de novo expression of MHC Class II, which creates a two-signal response from T Cells.
  • Advantage
    • Interaction with both T Helper cells and cytotoxic T Cells;
    • Strong Cancer specific immune response;
    • Multi-antigen signaling/response;
    • High patient specificity (autologous cell therapy).

Patent Protection

The Company has a strong intellectual property foundation and has an extensive patent portfolio on its platform and its lead product FK-PC101. The Company's patents provide protection until 2038 and provide potential licensors with significant time to generate revenue.

On its lead product, FK-PC101, the coverage includes composition of matter and method of use and preparation patents.

With respect to its discovery platform, the coverage includes the discovery process, product engineering and manufacturing and associated processes.

Issued Patents

  • Belgium Belgium
  • Brazil Brazil
  • France France
  • Germany Germany
  • Ireland Ireland
  • Japan Japan
  • Netherlands Netherlands
  • Switzerland Switzerland
  • United Kingdom United Kingdom
  • USA United States


Pending Patents

  • Canada Canada
  • Hong Kong Hong Kong
  • India India
  • South Korea South Korea

Outpatient injection procedure

Contact us

controller@cellvx.com

Send a message

PLEASE NOTE: CELLVAX THERAPEUTICS INC. IS NOT AFFILIATED WITH THE CRO CELLVAX SAS.

FK Biotec215 642 8954
FK Biotec Cellvax Therapeutics Inc.

1650 | Market Street | Suite 3500
Philadelphia | PA | 19103